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Antimicrobial peptides nanodelivery systems based on Aptamers/Mesoporous silica nanoparticles

Phare Action: Antibiotic-resistant pathogens

- Antimicrobial peptides nanodelivery systems based on Aptamers/Mesoporous silica nanoparticles

Antibiotic resistance is a major public health problem requiring the search for new therapeutic approaches. The objective of the ALES project is to develop antimicrobial peptide delivery systems with high affinity and specificity for the targetted pathogenic bacteria.

Antimicrobial peptides (AMPs) have many advantages. They have a rapid bactericidal activity and a broad spectrum of action but most importantly, resistance to AMPs is rare in contrast to antibiotic resistance. However, their toxicity and low specificity limit their clinical use. Encapsulation of AMPs in nano-sized carriers could overcome these drawbacks. Unfortunately, AMPs have already been encapsulated in several nanostructures that have not increased their specificity. The use of hybrid aptamer/nanoparticle mesoporous silica materials could provide an answer to this problem. Resolutely interdisciplinary, the ALES project requires skills in the field of aptamer science, analytical chemistry, pharmaceutical formulation, nanomaterial synthesis and microbiology. The ALES project will therefore be based on a close collaboration between three complementary partners.

- Funding Agence Nationale de la Recherche: 371.8 k€
- Coordination: Éric PEYRIN
- Project duration: 42 months
- Partners: Département de Pharmacochimie Moléculaire UMR 5063 (Grenoble), Laboratoire Chrono-environnement UMR 6249 (Besançon), Institut Néel UPR-2940 (Grenoble)
- Keywords: antibiotic resistance, antimicrobial peptides, encapsulation, nanoparticles

More about the ALES project

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