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Research > Actions & Projects > PATHOGENES Research Topic

Axis 1 - Dissemination of human pathogens

The dissemination of human pathogens (HP) is studied using collections of micro-organisms isolated from samples of human origin, but also from the environment (professional, domestic, hospital) and animals (livestock and wildlife).

Researchers in this theme work on community and/or hospital-acquired HP. Consequently, they integrate ’natural’ environmental reservoirs (water, soil, air) and hospital reservoirs (air, water networks, surfaces) into their analysis, thanks to sensors or environmental samples, but also human samples, from healthy or infected subjects, hospitalised or not. Understanding the spread of HP requires the constitution of collections on a large scale of time and space. Thus, the micro-organisms on which the researchers in this theme are working have been collected in several countries (Germany, Spain, the United States, the United Kingdom, etc.) and over long periods of time (on the scale of centuries for palaeo-microbiologists).

The aim is to decipher the mode of propagation of pathogens and the eco-epidemiology of infectious diseases. The methods used are based on the comparison of phenotypes and genotypes of HP.
These strategies allow :

  1. identify the characteristics of HP and the environmental and host conditions that favour their spread,
  2. develop predictive models of the risk of HP emergence at several spatial and temporal scales, and
  3. to develop tools to anticipate and control current and future epidemics.

The fight against the spread of HP also involves improving primary and secondary screening tools for certain infections and/or their consequences, including, for example, the precise characterisation of the phenomenon of vaccine hesitation and the improvement of cervical cancer screening (improvement of performance and women’s experience) induced by human papillomaviruses (HPV).

- ToAxis 2 - Antimicrobial resistance (AMR)
- ToAxis 3 - Host-pathogen interaction

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