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Alexandre Tétard thesis defense

Alexandre Tétard->] is pleased to invite you to the defense of his doctoral thesis on Friday, December 17, 2021, at 9 am, at the Bio-innovation Building, 4 rue Charles Bried, 25000 Besançon. His thesis is entitled Induction of efflux systems by electrophilic molecules in the bacterium Pseudomonas aeruginosa.
Due to the health situation, it is necessary to contact Alexandre to access the defense (alexandre.tetard at

Composition of the jury
Reporter: Pr Geneviève Hery-Arnaud
Rapporteur: Pr Jean-Michel Bolla
Examiner: Pr Marie-Geneviève Dijoux-Franca
Examiner: Pr Jean-Marie Perrier-Cornet
Thesis director: Dr Catherine Llanes
Co-director of the thesis: Pr Patrick Plésiat

Faced with the development of antibiotic resistance and the reduction in the number of therapeutic molecules available, the use of essential oils (EOs) is an alternative that may seem attractive. However, in some cases, the use of EOs is done in parallel with antibiotic treatments. Our work sought to establish the effect of EOs on the antibiotic susceptibility of the bacterium Pseudomonas aeruginosa by targeting two compounds contained in EOs: cinnamaldehyde and citral.
Used at sub-inhibitory concentrations, these two compounds show significant antagonism with many antibiotics due to the overproduction of efflux pumps, bacterial defence mechanisms that expel toxic molecules from the bacteria, but also chemical interactions with antibiotics, rendering them inactive.
It is therefore important to communicate well on the use of EOs and to pass on the message that these natural compounds in self-service are not without side effects, especially when they are consumed with antibiotics.

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