Chrono-environnement - UMR 6249 CNRS/UFC
Campus de la Bouloie
16 rue de Gray
25030 Besançon cedex
France
Michel Fromm
Professor – UFC
POLLUTION
michel.fromm@-Code to remove to avoid SPAM-univ-fcomte.fr
+33 (0)3 81 66 65 60, room 300K (La Bouloie)
0000-0002-3344-7621 michel-fromm
Radiochemistry – Low-energy electrons (1-20 eV) – Nuclear traces in solids – Tritium in the environment – Ultra-soft X-rays
Presentation
Head of the Radiation and Matter unit at the PEA²t platform
We have produced and characterized nanometric deposits of plasmid DNA complexed with molecules of biological interest (amino acids). Our collaboration with Prof. Sanche’s team (Sherbrooke, Canada) enables us to analyze the resonant dissociative attachment of low-energy electrons (1-15 eV) to DNA and other smaller molecules. More generally, my work aims to understand in detail the action of ionizing radiation on living or inert matter. The use of an ultra-soft X-ray generator (1.5 keV) has highlighted the contribution of hydrogen peroxide to the radiosensitizing effect of gold nanoparticles. This work is currently being pursued with a Japanese team from the National Institute of Radiological Sciences, Chiba (NIRS).
Projects
- Mécanismes de radiosensibilisation par les nanoparticules d’or. Stéphane Roux, Rana Bazzi (Laboratoire Chrono-Environnement, UMR 6249 CNRS), Tamon Kusumoto, Satoshi Kodaira (NIRS, Japon).
- Utilisation de gels dosimétriques en médecine nucléaire. Thèse de doctorat de M. Ahcène Benkemouche. Régine Gschwind, Yannick Bailly (Laboratoire Chrono-Environnement, UMR 6249 CNRS – Intitut FEMTO-ST UMR 6174 CNRS), Ahcène Benkemouche, Vincent Pagès, Institut Paoli-Calmettes (IPC), Marseille.
Publications
Journal articles
2024
- ref_biblio
- Yu Okazaki, Tamon Kusumoto, Stephane Roux, Ryoichi Hirayama, Michel Fromm, et al.. Increase of OH radical yields due to the decomposition of hydrogen peroxide by gold nanoparticles under X-ray irradiation. RSC Advances, 2024, 14 (14), pp.9509-9513. ⟨10.1039/d4ra00208c⟩. ⟨hal-04626333⟩
- Accès au texte intégral et bibtex
2023
- ref_biblio
- Norhan Omar, Pierre Cloutier, Christophe Ramseyer, Léon Sanche, Michel Fromm. The role of repulsive and attractive forces in low-energy (3–15 eV) electron stimulated desorption of anions from molecular layers grown on clean and contaminated metallic substrates. Chemical Physics, 2023, 564, pp.111661. ⟨10.1016/j.chemphys.2022.111661⟩. ⟨hal-04226805⟩
- Accès au texte intégral et bibtex
2021
- ref_biblio
- M. A. Al-Jubbori, Michel Fromm, E. M. Awad. Strong etching formulation (time and rate) for PADC with deep depth bulk etch rate study. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2021, 1005, pp.165402. ⟨10.1016/j.nima.2021.165402⟩. ⟨hal-03557805⟩
- Accès au texte intégral et bibtex
- ref_biblio
- Michel Fromm, M. Abu-Shady, J.E. E Groetz, E.M. M Awad. Etched track profiles for relativistic 7 GeV Silicon and 17.48 GeV Nickel ions in PADC detector: The case study of convex track walls. Radiation Physics and Chemistry, 2021, 187, pp.109566. ⟨10.1016/j.radphyschem.2021.109566⟩. ⟨hal-03557788⟩
- Accès au texte intégral et bibtex
- ref_biblio
- A.F. F Saad, Michel Fromm, Mona H Ibraheim, A.A. A El-Namrouty, Aya M Nwara, et al.. Loss of chemical bonds induced by high doses of γ-radiation in a PADC polymer film: The influence of dose and dose rate on radiation chemical yields. Radiation Physics and Chemistry, 2021, 187, pp.109579. ⟨10.1016/j.radphyschem.2021.109579⟩. ⟨hal-03557764⟩
- Accès au texte intégral et bibtex
2020
- ref_biblio
- Jean-Emmanuel Groetz, Tamon Kusumoto, Shogo Okada, Hisaya Kurashige, Kazuo Kobayashi, et al.. Evidence for a critical dose above which damage to carbonate ester bonds in PADC appear after gamma ray and ultra soft X-ray exposures. Radiation Physics and Chemistry, 2020, 170, ⟨10.1016/j.radphyschem.2019.108628⟩. ⟨hal-03549049⟩
- Accès au texte intégral et bibtex
2019
- ref_biblio
- Michel Fromm, Satoshi Kodaira, Tamon Kusumoto, Rémi Barillon, Tomoya Yamauchi. Role of intermediate species in the formation of ion tracks in PADC: A review. Polymer Degradation and Stability, 2019, 161, pp.213 - 224. ⟨10.1016/j.polymdegradstab.2019.01.028⟩. ⟨hal-03558134⟩
- Accès au texte intégral et bibtex
- ref_biblio
- Talat Tariq Khalil, Rana Bazzi, Stéphane Roux, Michel Fromm. The contribution of hydrogen peroxide to the radiosensitizing effect of gold nanoparticles. Colloids and Surfaces B: Biointerfaces, 2019, 175, pp.606-613. ⟨10.1016/j.colsurfb.2018.12.041⟩. ⟨hal-03558105⟩
- Accès au texte intégral et bibtex
2018
- ref_biblio
- Michel Fromm, Béatrice Sjöberg, Sarah Foley, Bruno Cardey, Mironel Enescu. Methionine oxidation by hydrogen peroxide in peptides and proteins: A theoretical and Raman spectroscopy study. Journal of Photochemistry and Photobiology B: Biology, 2018, 188, pp.95-99. ⟨10.1016/j.jphotobiol.2018.09.009⟩. ⟨hal-03558167⟩
- Accès au bibtex
- ref_biblio
- Tamon Kusumoto, Michel Fromm, Pierre Cloutier, Andrew D Bass, Léon Sanche, et al.. Elucidation of the Two-step Damage Formation Process of Latent Tracks in Poly(allyl diglycol carbonate), PADC: Role of Secondary Low-energy Electrons. Journal of Physical Chemistry C, 2018, 122 (36), pp.21056-21061. ⟨10.1021/acs.jpcc.8b05341⟩. ⟨hal-03559895⟩
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- ref_biblio
- Tamon Kusumoto, Ziad El Bitar, Shogo Okada, Pierre Gillet, Nicolas Arbor, et al.. Radial electron fluence around ion tracks as a new physical parameter for the detection threshold of PADC using Geant4-DNA toolkit. Radiat.Meas., 2018, 118, pp.50-53. ⟨10.1016/j.radmeas.2018.08.015⟩. ⟨hal-02268455⟩
- Accès au bibtex
- ref_biblio
- Béatrice Sjöberg, Sarah Foley, Bruno Cardey, Michel Fromm, Mironel Enescu. Methionine oxidation by hydrogen peroxide in peptides and proteins: A theoretical and Raman spectroscopy study. Journal of Photochemistry and Photobiology B: Biology, 2018, 188, pp.95-99. ⟨10.1016/j.jphotobiol.2018.09.009⟩. ⟨hal-03526830⟩
- Accès au bibtex
2017
- ref_biblio
- T.T. Khalil, O. Boulanouar, O. Heintz, Michel Fromm. Auto-assembly of nanometer thick, water soluble layers of plasmid DNA complexed with diamines and basic amino acids on graphite: Greatest DNA protection is obtained with arginine. Materials Science and Engineering: C, 2017, 71, pp.231 - 239. ⟨10.1016/j.msec.2016.10.011⟩. ⟨hal-03559916⟩
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- ref_biblio
- Mounir Souici, Talat T. Khalil, Dominique Muller, Quentin Raffy, Rémi Barillon, et al.. Single- and Double-Strand Breaks of Dry DNA Exposed to Protons at Bragg-Peak Energies. Journal of Physical Chemistry B, 2017, 121 (3), pp.497 - 507. ⟨10.1021/acs.jpcb.6b11060⟩. ⟨hal-01559863⟩
- Accès au bibtex
2016
- ref_biblio
- Michel Fromm, Omar Boulanouar. Low energy electrons and ultra-soft X-rays irradiation of plasmid DNA. Technical innovations. Radiation Physics and Chemistry, 2016, 128, pp.44 - 53. ⟨10.1016/j.radphyschem.2016.05.025⟩. ⟨hal-03558190⟩
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- ref_biblio
- Pierre Le Goff, Philippe Guétat, Laurent Vichot, Nicolas Leconte, P.M. Badot, et al.. Tritium levels in milk in the vicinity of chronic tritium releases. Journal of Environmental Radioactivity, 2016, 151, pp.282-292. ⟨10.1016/j.jenvrad.2015.10.022⟩. ⟨hal-04522960⟩
- Accès au bibtex
2014
- ref_biblio
- M Benabdeslem, A Bouasla, N Benslim, L Bechiri, S Mehdaoui, et al.. Zn incorporation in CuInSe2: Particle size and strain effects on microstructural and electrical properties. Bulletin of Materials Science, 2014, 37 (3), pp.469-472. ⟨10.1007/s12034-014-0687-9⟩. ⟨hal-01150456⟩
- Accès au bibtex
- ref_biblio
- Christophe Champion, Sébastien Incerti, Yann Perrot, Rachel Delorme, Marie-Claude Bordage, et al.. Dose point kernels in liquid water: An intra-comparison between GEANT4-DNA and a variety of Monte Carlo codes. Applied Radiation and Isotopes, 2014, 83 (Part B), pp.137-141. ⟨10.1016/j.apradiso.2013.01.037⟩. ⟨hal-00858479⟩
- Accès au texte intégral et bibtex
- ref_biblio
- J.-E Groetz, Nabil Ounoughi, C Mavon, A Belafrites, M Fromm. Conception and realization of a parallel-plate free-air ionization chamber for the absolute dosimetry of an ultrasoft X-ray beam. Review of Scientific Instruments, 2014, 85, pp.83304. ⟨10.1063/1.4890817⟩. ⟨hal-01117735⟩
- Accès au texte intégral et bibtex
- ref_biblio
- Pierre Le Goff, Jean-Marie Duda, Philippe Guétat, Pauline Rambaud, Christophe Mavon, et al.. Measurement of tritium in the free water of milk : spotting and quantifying some biases and proposing ways of improvement. Journal of Environmental Radioactivity, 2014, 127, pp.1-10. ⟨10.1016/j.jenvrad.2013.09.006⟩. ⟨hal-01117741⟩
- Accès au texte intégral et bibtex
- ref_biblio
- Pierre Le Goff, Michel Fromm, Laurent Vichot, Pierre-Marie Badot, Philippe Guétat. Isotopic fractionation of tritium in biological systems. Environment International, 2014, 65, pp.116 - 126. ⟨10.1016/j.envint.2013.12.020⟩. ⟨hal-01117744⟩
- Accès au texte intégral et bibtex
2013
- ref_biblio
- Omar Boulanouar, Michel Fromm, Christophe Mavon, Pierre Cloutier, Léon Sanche. Dissociative electron attachment to DNA-diamine thin films: Impact of the DNA close environment on the OH(-) and O(-) decay channels.. The Journal of Chemical Physics, 2013, 139 (5), pp.055101. ⟨10.1063/1.4815967⟩. ⟨hal-00858438⟩
- Accès au texte intégral et bibtex
- ref_biblio
- Omar Boulanouar, Michel Fromm, Andrew D Bass, Pierre Cloutier, Léon Sanche. Absolute cross section for loss of supercoiled topology induced by 10 eV electrons in highly uniform ∕DNA∕1,3-diaminopropane films deposited on highly ordered pyrolitic graphite.. The Journal of Chemical Physics, 2013, 139 (5), pp.055104. ⟨10.1063/1.4817323⟩. ⟨hal-00858430⟩
- Accès au texte intégral et bibtex
- ref_biblio
- Géraldine Gonon, Jean-Emmanuel Groetz, Sonia M de Toledo, Roger W Howell, Michel Fromm, et al.. Non-targeted Stressful Effects in Normal Human Fibroblast Cultures Exposed to Low Fluences of High Charge, High-Energy (HZE) Particles: Kinetics of Biologic Responses and Significance of Secondary Radiations.. Radiation Research, 2013, epub ahead of print. ⟨10.1667/RR3017.1⟩. ⟨hal-00801993⟩
- Accès au texte intégral et bibtex
- ref_biblio
- Nabil Ounoughi, Christophe Mavon, Abdelfettah Belafrites, Jean-Emmanuel Groetz, Michel Fromm. Beam characterization of a lab bench cold cathode ultra-soft X-ray generator. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2013, 305, pp.61-66. ⟨10.1016/j.nimb.2013.04.050⟩. ⟨hal-00858423⟩
- Accès au texte intégral et bibtex
2011
- ref_biblio
- Omar Boulanouar, Abderrahim Khatyr, Guillaume Herlem, Frank Palmino, Léon Sanche, et al.. Soft adsorption of densely packed layers of DNA-plasmid * 1,3-diaminopropane complexes onto highly oriented pyrolytic graphite designed to erode in water. Journal of Physical Chemistry C, 2011, 115 (43), pp.21291-21298. ⟨10.1021/jp207083r⟩. ⟨hal-00733967⟩
- Accès au texte intégral et bibtex
2009
- ref_biblio
- E.M. Awad, Valery Ditlov, Michel Fromm, Dietrich Hermsdorf. Description of the bulk etching rate of CR-39 by an extended Arrhenius-like law in increased intervalls of temperature and etchant concentration. Radiation Measurements, 2009, 44 (9-10), pp.813-820. ⟨10.1016/j.radmeas.2009.10.087⟩. ⟨hal-00516089⟩
- Accès au bibtex
- ref_biblio
- Claudine Boyer, L. Vichot, Michel Fromm, Y. Losset, F. Tatin-Froux, et al.. Tritium in plants: A review of current knowledge. Environmental and Experimental Botany, 2009, 67 (1), pp.34-51. ⟨10.1016/j.envexpbot.2009.06.008⟩. ⟨hal-00516075⟩
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- ref_biblio
- Cécile Boyer, Laurent Vichot, T. Boissieux, Yvan Losset, Christophe Mavon, et al.. Variations of conversion rate from Tissue Free Water Tritium to Organically-Bound Tritium in lettuces continuously exposed to atmospheric HT and HTO. Radioprotection, 2009, 44 (5), pp.671-676. ⟨hal-00394424⟩
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- ref_biblio
- Emilie Brun, Pierre Cloutier, Cécile Sicard-Roselli, Michel Fromm, Léon Sanche. Damage induced to DNA by low-energy (0-30 eV) electrons under vacuum and atmospheric conditions.. Journal of Physical Chemistry B, 2009, 113 (29), pp.10008-13. ⟨10.1021/jp902540k⟩. ⟨hal-00515989⟩
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- ref_biblio
- Michel Fromm. Propagation Distance of the α-Particle-Induced Bystander Effect: The Role of Nuclear Traversal and Gap Junction Communication. Radiation Research, 2009, 171 (5), pp.513-520. ⟨10.1667/RR1658.1⟩. ⟨hal-00515975⟩
- Accès au bibtex
2008
- ref_biblio
- Eric Mboungou, Christophe Mavon, Jean-Michel Friedt, Christelle Bergeon, Michel Fromm. Impact of Water Content on the Electrical Behavior of Epoxy Insulators. IEEE Transactions on Dielectrics and Electrical Insulation, 2008, 15 (2), pp.311-318. ⟨10.1109/TDEI.2008.4483447⟩. ⟨hal-00516096⟩
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- ref_biblio
- Antoine Mougin, Valéry G. Babak, Frank Palmino, Eric Bêche, Francis Baros, et al.. TDAB-induced DNA plasmid condensation on the surface of a reconstructed boron doped silicon substrate. Surface Science : A Journal Devoted to the Physics and Chemistry of Interfaces, 2008, 602 (1), pp.142-150. ⟨10.1016/j.susc.2007.09.058⟩. ⟨hal-00516052⟩
- Accès au texte intégral et bibtex
2007
- ref_biblio
- Stéphane Goyard, Vincent Lavoine, Pierre Gareil, Michel Fromm, Jean-Charles Hubinois. Evaluation of different nebulizers and spray chambers for the on-line coupling of ion chromatography with ICP-OES. Journal of Analytical Atomic Spectrometry, 2007, 22, pp.1507-1511. ⟨10.1039/b705793h⟩. ⟨hal-00516113⟩
- Accès au bibtex
2006
- ref_biblio
- Michel Fromm, Emmanuel Groetz Jean. Des détecteurs de traces à la radiobiologie : la contribution du LMN-AC. Radioprotection, 2006, 41 (5), pp.S131 - S148. ⟨10.1051/radiopro:2007020⟩. ⟨hal-00516062⟩
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- ref_biblio
- Jean-Baptiste Sanchez, Franck Berger, Michel Fromm, Marie-Hélène Nadal. A selective gas detection micro-device for monitoring the volatile organic compounds pollution. Sensors and Actuators, 2006, 119 (1), pp.227-233. ⟨10.1016/j.snb.2005.12.028⟩. ⟨hal-00516125⟩
- Accès au bibtex
2005
- ref_biblio
- Michel Fromm, Franck Berger, Marie-Hélène Nadal, Jean-Baptiste Sanchez. Use of a chromatographic column to improve the selectivity of the SnO2 gas sensors: first approach towards a miniaturised device and selective with hydrogen fluoride vapours. Sensors and Actuators B: Chemical, 2005, 106 (2), pp.823-831. ⟨10.1016/j.snb.2004.10.002⟩. ⟨hal-00516131⟩
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- ref_biblio
- Sylvain Gaillard, Vincent Armbruster, Mark A Hill, Tijani Gharbi, Michel Fromm. Production and validation of CR-39-based dishes for alpha-particle radiobiological experiments. Radiation Research, 2005, 163 (3), pp.343-350. ⟨10.1667/rr3307⟩. ⟨hal-00516007⟩
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2003
- ref_biblio
- Michel Fromm, D. Pusset, H. Boulahdour, Poncy J. L., B. Kantelip, et al.. Ultrastructural apoptotic lesions induced in bone marrow after neptunium-237 contamination. Anticancer Research, 2003, 23 (6C), pp.4837-4842. ⟨hal-00516140⟩
- Accès au bibtex
1995
- ref_biblio
- Pascal Meyer, Michel Fromm, Alain Chambaudet, Jl Laugier, Libor Makovicka. A computer simulation of (n,p) conversion and resulting proton tracks etched in CR39 SSNTD. Radiation Measurements, 1995, 25 (1-4), pp.449-452. ⟨hal-00425902⟩
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Conference papers
2013
- ref_biblio
- Géraldine Gonon, Jean-Emmanuel Groetz, Sonia M de Toledo, Roger Howell, Michel Fromm, et al.. Low fluences of High Charge, High Energy (HZE) particles: kinetics of biologic responses and significance of secondary radiations. NEUDOS 12 - Neutron and Ion Dosimetry Symposium, Jun 2013, Aix en provence, France. ⟨hal-00862229⟩
- Accès au bibtex
- ref_biblio
- Pierre Le Goff, Jean-Marie Duda, Philippe Guétat, Michel Fromm. Extraction de l'eau libre d'une matrice et mesures de l'activité tritium. SFRP 2013, Jun 2013, Bordeaux Lac, France. ⟨hal-00862410⟩
- Accès au bibtex
2011
- ref_biblio
- Omar Boulanouar, Pierre Cloutier, Léon Sanche, Michel Fromm. Condensation d'ADN plasmidique par des diamines sur un substrat de graphite HOPG. 79 ième congrès de l'ACFAS, May 2011, Sherbrooke, Canada. ⟨hal-00862423⟩
- Accès au texte intégral et bibtex
- ref_biblio
- Omar Boulanouar, Lionel Amiaud, Michel Fromm, Cécile Sicard-Roselli, Léon Sanche, et al.. Neutral Products Desorption from DNA Thin Films Induced by Low-Energy Electrons (0.5-20 eV). 1st Nano-IBCT conference 2011, Radiation damage of Biological Systems: Nano-scale Insights into Ion Beam Cancer Therapy, Oct 2011, Caen, France. ⟨hal-00862327⟩
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- ref_biblio
- Guillermo Espinosa, Lluis Font, Michel Fromm. A review of the developments in nuclear track methodology as published in the proceedings of the International Conference on Nuclear Tracks in Solids from 1990 to 2008. 25th Int. Conf. on Nuclear Tracks in Solids, Sep 2011, Puebla, Mexico. pp.1-6. ⟨hal-00821904⟩
- Accès au texte intégral et bibtex
2010
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- Géraldine Gonon, Sonia M de Toledo, Michel Fromm, Edouard I Azzam. Kinetics of propagation of bystander effects in human cells cultures exposed to low fluences of high LET radiations. 56th Annual Meeting Radiation Research Society, Sep 2010, Maui, United States. ⟨hal-00862316⟩
- Accès au texte intégral et bibtex
2004
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- David Pusset, Michel Fromm, Hatem Boulahdour, Takao Tsuruta. Fission fragment track etching modelling for the cellular localisation of Neptunium-237 nuclei in rat tissues. 22nd International Conference on Nuclear Tracks in Solids, Aug 2004, Barcelona, France. pp.289-294, ⟨10.1016/j.radmeas.2005.06.032⟩. ⟨hal-00516106⟩
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