Stéphane ROUX

Chrono-environnement - UMR 6249 CNRS/UFC
Campus de la Bouloie
16 rue de Gray
25030 Besançon cedex
France

Stéphane Roux

Professor – UFC
POLLUTION

stephane.roux@-Code to remove to avoid SPAM-univ-fcomte.fr
+33 (0)3 81 66 62 99, room 308K (La Bouloie)

Student :

ORCID logo 0000-0002-5198-1916   HAL logo stephane-roux6249

   

Nanosciences – Synthesis, functionalisation and characterisation of hybrid materials – Multifunctional nanoparticles – Targeting – Medical imaging

Présentation

My research focuses on the development of hybrid nanostructures (organic and inorganic components entangled on a nanometric scale) for medical applications. I am interested in the design of nanostructures that combine several medical imaging modalities with at least one remote-controlled therapeutic activity for targeted, image-guided therapy.

Projets

  • EUR EIPHI-Intherapi : CIMES – Ciblage actif par chimie clic in vivo d’agents théranostiques dans le cadre de la thérapie guidée par imagerie des glioblastomes
  • ANR PRC : nanoHyMPI – nanofleurs magnétoplasmoniques pour le traitement de l’athérosclérose guidé par imagerie

 

Publications

Journal articles

2024

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Yu Okazaki, Tamon Kusumoto, Stephane Roux, Ryoichi Hirayama, Michel Fromm, et al.. Increase of OH radical yields due to the decomposition of hydrogen peroxide by gold nanoparticles under X-ray irradiation. RSC Advances, 2024, 14 (14), pp.9509-9513. ⟨10.1039/d4ra00208c⟩. ⟨hal-04626333⟩
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2023

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Maxime Durand, Alicia Chateau, Justine Jubréaux, Jérôme Devy, Héna Paquot, et al.. Radiosensitization with Gadolinium Chelate-Coated Gold Nanoparticles Prevents Aggressiveness and Invasiveness in Glioblastoma. International Journal of Nanomedicine, 2023, 18, pp.243-261. ⟨10.2147/IJN.S375918⟩. ⟨hal-03957559⟩
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https://hal.science/hal-03957559/file/Durand%2C%20Int%20J%20NANOMED%2C%202023.pdf BibTex
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Théotim Lucas, Clément Linger, Thomas Naillon, Mahshid Hashemkhani, Lise Abiven, et al.. Quantitative, precise and multi-wavelength evaluation of the light-to-heat conversion efficiency for nanoparticular photothermal agents with calibrated photoacoustic spectroscopy. Nanoscale, 2023, ⟨10.1039/D3NR03727D⟩. ⟨hal-04247769⟩
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2022

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Agnieszka Paściak, Riccardo Marin, Lise Abiven, Aleksandra Pilch-Wróbel, Małgorzata Misiak, et al.. Quantitative Comparison of the Light-to-Heat Conversion Efficiency in Nanomaterials Suitable for Photothermal Therapy. ACS Applied Materials & Interfaces, 2022, 14 (29), pp.33555-33566. ⟨10.1021/acsami.2c08013⟩. ⟨hal-03805064⟩
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https://hal.sorbonne-universite.fr/hal-03805064/file/acsami.2c08013.pdf BibTex

2021

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Gautier Laurent, Chahrazad Benbalit, Claire Chrétien, Constantin Dupuis, Yann Pellequer, et al.. Characterization and biodistribution of Au nanoparticles loaded in PLGA nanocarriers using an original encapsulation process. Colloids and Surfaces B: Biointerfaces, 2021, 205, pp.111875. ⟨10.1016/j.colsurfb.2021.111875⟩. ⟨hal-03593149⟩
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https://hal.science/hal-03593149/file/S0927776521003192.pdf BibTex
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Alba Nicolás-Boluda, Gautier Laurent, Rana Bazzi, Stéphane Roux, Emmanuel Donnadieu, et al.. Two step promotion of a hot tumor immune environment by gold decorated iron oxide nanoflowers and light-triggered mild hyperthermia. Nanoscale, 2021, 13 (44), pp.18483-18497. ⟨10.1039/d1nr03201a⟩. ⟨hal-03453139⟩
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2020

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Vladimir Ivošev, Gloria Jiménez Sánchez, Lenka Stefancikova, Darine Abi Haidar, César R. González Vargas, et al.. Uptake and excretion dynamics of gold nanoparticles in cancer cells and fibroblasts. Nanotechnology, 2020, 31 (13), pp.135102. ⟨10.1088/1361-6528/ab5d82⟩. ⟨hal-02483954⟩
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Vincent Motto-Ros, V Gardette, L Sancey, M Leprince, D Genty, et al.. LIBS-Based Imaging: Recent Advances and Future Directions. Journal of Spectroscopy, 2020, 35 (2), pp.34-40. ⟨hal-02998713⟩
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https://hal.science/hal-02998713/file/71-2020-SPEC_Motto-Ros.pdf BibTex
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Alba Nicolás-Boluda, Javier Vaquero, Gautier Laurent, Gilles Renault, Rana Bazzi, et al.. Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma. ACS Nano, 2020, 14 (5), pp.5738-5753. ⟨10.1021/acsnano.0c00417⟩. ⟨hal-02746158⟩
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https://hal.science/hal-02746158/file/Manuscript%20ACSNano-%20FINAL%20%281%29.pdf BibTex
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Evangelia-Alexandra Salvanou, Dimitris Stellas, Charalampos Tsoukalas, Barbara Mavroidi, Maria Paravatou-Petsotas, et al.. A Proof-of-Concept Study on the Therapeutic Potential of Au Nanoparticles Radiolabeled with the Alpha-Emitter Actinium-225. Pharmaceutics, 2020, 12 (2), pp.188. ⟨10.3390/pharmaceutics12020188⟩. ⟨hal-02733784⟩
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2019

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Sandrine Dufort, Geoffrey Appelboom, Camille Verry, Emmanuel L. Barbier, François Lux, et al.. Ultrasmall theranostic gadolinium-based nanoparticles improve high-grade rat glioma survival. Journal of Clinical Neuroscience, 2019, 67, pp.215-219. ⟨10.1016/j.jocn.2019.05.065⟩. ⟨hal-02337558⟩
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https://hal.science/hal-02337558/file/67-2019-Ultrasmall%20theranostic%20gadolinium-based%20nanoparticles%20improve%20high-grade%20rat%20glioma%20survival%20%281%29.pdf BibTex
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Talat Tariq Khalil, Rana Bazzi, Stéphane Roux, Michel Fromm. The contribution of hydrogen peroxide to the radiosensitizing effect of gold nanoparticles. Colloids and Surfaces B: Biointerfaces, 2019, 175, pp.606-613. ⟨10.1016/j.colsurfb.2018.12.041⟩. ⟨hal-03558105⟩
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https://hal.science/hal-03558105/file/Hydrogen%20peroxide%20-%20GNP.pdf BibTex
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Alexis Loiseau, Julien Boudon, Alexandra Oudot, Mathieu Moreau, Romain Boidot, et al.. Titanate Nanotubes Engineered with Gold Nanoparticles and Docetaxel to Enhance Radiotherapy on Xenografted Prostate Tumors. Cancers, 2019, 11 (12), pp.1962. ⟨10.3390/cancers11121962⟩. ⟨hal-02735286⟩
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https://hal.science/hal-02735286/file/cancers-11-01962-v2.pdf BibTex
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Eva Pagáčová, Lenka Štefančíková, Franz Schmidt-Kaler, Georg Hildenbrand, Tomáš Vičar, et al.. Challenges and Contradictions of Metal Nano-Particle Applications for Radio-Sensitivity Enhancement in Cancer Therapy. International Journal of Molecular Sciences, 2019, 20 (3), pp.588. ⟨10.3390/ijms20030588⟩. ⟨hal-02735347⟩
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2018

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Gabriel de Crozals, David Kryza, Gloria Jiménez Sánchez, Stéphane Roux, Doriane Mathé, et al.. Granulocyte Colony-Stimulating Factor Nanocarriers for Stimulation of the Immune System (Part I): Synthesis and Biodistribution Studies. Bioconjugate Chemistry, 2018, 29 (3), pp.795 - 803. ⟨10.1021/acs.bioconjchem.7b00605⟩. ⟨hal-01767382⟩
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Vu-Long Tran, Vivek Thakare, Marco Natuzzi, Mathieu Moreau, Alexandra Oudot, et al.. Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/ 64 Cu PET Imaging. Contrast Media and Molecular Imaging, 2018, 2018, pp.1-10. ⟨10.1155/2018/7938267⟩. ⟨hal-02130026⟩
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2016

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Karl Butterworth, James Nicol, Mihaela Ghita, Soraia Rosa, Pankaj Chaudhary, et al.. Preclinical evaluation of gold-DTDTPA nanoparticles as theranostic agents in prostate cancer radiotherapy. Nanomedicine, 2016, 11 (16), pp.2035-2047. ⟨10.2217/nnm-2016-0062⟩. ⟨hal-01405741⟩
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Sandrine Dufort, Géraldine Le Duc, Murielle Salomé, Valerie Bentivegna, Lucie Sancey, et al.. The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors. Scientific Reports, 2016, 6, pp.29678. ⟨10.1038/srep29678⟩. ⟨hal-01405772⟩
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Ali Houmed Adabo, Rabah Zeggari, Nasser Mohamed Said, Rana Bazzi, Céline Elie-Caille, et al.. Enhanced chemiluminescence-based detection on gold substrate after electrografting of diazonium precursor-coated gold nanoparticles. Journal of Colloid and Interface Science, 2016, 467, pp.271-279. ⟨10.1016/j.jcis.2016.01.030⟩. ⟨hal-01363650⟩
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2015

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François Lux, Lucie Sancey, Andrea Bianchi, Yannick Crémillieux, Stéphane Roux, et al.. Gadolinium-based nanoparticles for theranostic MRI-radiosensitization. Nanomedicine, 2015, 10 (11), pp.1801-1815. ⟨10.2217/NNM.15.30⟩. ⟨hal-01275075⟩
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Vijetha Mogilireddy, Isabelle Déchamps-Olivier, Christophe Alric, Gautier Laurent, Sophie Laurent, et al.. Thermodynamic stability and kinetic inertness of a Gd–DTPA bisamide complex grafted onto gold nanoparticles. Contrast Media and Molecular Imaging, 2015, 10 (3), pp.179-187. ⟨10.1002/cmmi.1616⟩. ⟨hal-01275116⟩
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2014

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Géraldine Le Duc, Stéphane Roux, Amandine Paruta-Tuarez, Sandrine Dufort, Elke Brauer, et al.. Advantages of gadolinium based ultrasmall nanoparticles vs molecular gadolinium chelates for radiotherapy guided by MRI for glioma treatment. Cancer Nanotechnology, 2014, 5 (1), pp.1-14. ⟨10.1186/s12645-014-0004-8⟩. ⟨hal-01115650⟩
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https://hal.science/hal-01115650/file/s12645-014-0004-8.pdf BibTex
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Lucie Sancey, François Lux, Shady Kotb, Stéphane Roux, Sandrine Dufort, et al.. The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy. British Journal of Radiology, 2014, 87 (1041), pp.20140134. ⟨10.1259/bjr.20140134⟩. ⟨hal-01053790⟩
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2013

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Olivier Pluchery, Hynd Remita, Pierre-François Brevet, Stéphane Roux. Keeping an eye on gold. Gold Bulletin : The journal of gold science, technology and applications , 2013, 46 (4), pp.211-212. ⟨10.1007/s13404-013-0131-8⟩. ⟨hal-03562584⟩
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https://hal.science/hal-03562584/file/Pluchery2013_Article_KeepingAnEyeOnGold.pdf BibTex
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Wael Rima, Lucie Sancey, Marie-Thérèse Aloy, Emma Armandy, B. Alcantara Gustavo, et al.. Internalization pathways into cancer cells of gadolinium-based radiosensitizing nanoparticles. Biomaterials, 2013, 34, pp.181-195. ⟨10.1016/j.biomaterials.2012.09.029⟩. ⟨hal-00757773⟩
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https://hal.science/hal-00757773/file/JP-Biomaterials-34-Orig.pdf BibTex

2011

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François Lux, Anna Mignot, Pierre Mowat, Cédric Louis, Sandrine Dufort, et al.. Ultrasmall rigid particles as multimodal probes for medical applications.. Angewandte Chemie International Edition, 2011, 50 (51), pp.12299-303. ⟨10.1002/anie.201104104⟩. ⟨inserm-00658275⟩
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https://inserm.hal.science/inserm-00658275/file/Lux_AngewandteChemie_2011_Vediteur.pdf BibTex
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Cédric Tissandier, Noël Diop, Matteo Martini, Stéphane Roux, Olivier Tillement, et al.. One-Pot Synthesis of Hybrid Multifunctional Silica Nanoparticles with Tunable Coating by Click Chemistry in Reverse W/O Microemulsion. Langmuir, 2011, pp.22066823. ⟨10.1021/la203580q⟩. ⟨hal-00650245⟩
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2010

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Matteo Martini, Stéphane Roux, Maurizio Montana, Robert Bernard Pansu, Carine Julien, et al.. How gold inclusions increase the rate of fluorescein energy homotransfer in silica beads. Chemical Physics Letters, 2010, 490 (1-3), pp.72. ⟨10.1016/j.cplett.2010.03.027⟩. ⟨hal-00558074⟩
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2009

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Matteo Martini, Pascal Perriat, Maurizio Montagna, Robert Bernard Pansu, Carine Julien, et al.. How Gold Particles Suppress Concentration Quenching of Fluorophores Encapsulated in Silica Beads. Journal of Physical Chemistry C, 2009, 113 (41), pp.17669-17677. ⟨10.1021/jp9044572⟩. ⟨hal-00529667⟩
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Meigui Ou, Brice Mutelet, Matteo Martini, Rana Bazzi, Stéphane Roux, et al.. Optimization of the synthesis of nanostructured Tb3+-doped Gd2O3 by in-situ luminescence following up. Journal of Colloid and Interface Science, 2009, 333 (2), pp.684-689. ⟨10.1016/j.jcis.2009.01.062⟩. ⟨hal-02116846⟩
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2008

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Christophe Alric, Jacqueline Taleb, Géraldine Le Duc, Celine Mandon, Claire Billotey, et al.. Gadolinium chelates coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging. Journal of the American Chemical Society, 2008, 130 (18), pp.5908-5915. ⟨10.1021/ja078176p⟩. ⟨ujm-00350670⟩
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Grégory Barbillon, Anne Charlotte Faure, Nayla El Kork, Pascal Moretti, Stéphane Roux, et al.. How nanoparticles encapsulating fluorophores allow a double detection of biomolecules by localized surface plasmon resonance and luminescence. Nanotechnology, 2008, pp.1. ⟨10.1088/0957-4484/19/03/035705⟩. ⟨hal-00433994⟩
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2006

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Guowei Lu, Bolin Cheng, Hong Shen, Zhenghao Chen, Guozhen Yang, et al.. Influence of the nanoscale structure of gold thin films upon peroxidase-induced chemiluminescence. Applied Physics Letters, 2006, 88, pp.8023903-023906. ⟨10.1063/1.2162701⟩. ⟨hal-00137472⟩
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Conference papers

2018

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Héna Paquot, Alicia Chateau, Paul Retif, Joël Daouk, Stéphane Roux, et al.. Radiosensitizing effect of gold-based nanoparticles for brain tumour treatment. 25th Biennial Congress of the European Association for Cancer Research, EACR25, Jun 2018, Amsterdam, Netherlands. ⟨10.1136/esmoopen-2018-EACR25.658⟩. ⟨hal-01967032⟩
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2008

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Christophe Alric, Jacqueline Taleb, Celine Mandon, Claire Billotey, Thierry Brochard, et al.. Gold nanoparticles designed for in vivo SRCT and MRI imaging and X-ray therapy. New prospects for brain tumour radiotherapy: Synchrotron light and Microbeam radiation Therapy (ESRF), Jun 2008, GRENOBLE, France. ⟨ujm-00404910⟩
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Grégory Barbillon, Anne-Charlotte Faure, Stéphane Roux, Olivier Tillement, Meigui Ou, et al.. Influence de nano-hybrides luminescents sur la cinétique d'adsorption de la streptavidine sur des nanoparticules métalliques, et nanotechnologie pour la biologie. GDR Nano-Hybrides 5, Jun 2008, Porquerolles, France. ⟨hal-02518922⟩
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2007

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Grégory Barbillon, Anne-Charlotte Faure, Nayla El Kork, Pascal Moretti, Stéphane Roux, et al.. Double détection de molécules biologiques utilisant la résonance de plasmons de surface localisés et la luminescence de nanohybrides sur des nanoparticules d'or. GDR Or-Nano 2007, Dec 2007, Lyon, France. ⟨hal-02518931⟩
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2006

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Sm Chabane Sari, Francis Vocanson, R. Lamartine, Pj Debouttiere, C. Dujardin, et al.. Grafting of colloidally stable gold nanoparticles with lissamine rhodamine B : towards more efficient biological tags. International Congress on Materials Science and Engineering 2006, 2006, TLEMCEN, Algeria. pp.267. ⟨ujm-00352696⟩
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Pj Debouttiere, Roger Lamartine, Francis Vocanson, Stéphane Roux, Olivier Tillement, et al.. Nanoparticules hybrides d'or pour l'IRM. Colloque Nanohybrides 3, 2006, France. ⟨ujm-00374949⟩
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Pj Debouttiere, R. Lamartine, Francis Vocanson, Stéphane Roux, Olivier Tillement, et al.. Elaboration de nanoparticules hybrides à cœur d'or pour des applications en IRM. MADICA 2006, 2006, Mahdia, Tunisie. ⟨ujm-00376170⟩
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2005

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Pj Debouttiere, Francis Vocanson, R. Lamartine, Olivier Tillement, Stéphane Roux, et al.. Elaboration de Nano-Hybrides d'or pour des applications biologiques. 19èmes Journées Surfaces et Interfaces, 2005, Villeurbanne, France. ⟨ujm-00376178⟩
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Pj Debouttiere, R. Lamartine, Francis Vocanson, Stéphane Roux, Olivier Tillement, et al.. Elaboration de nanohybrides à cœur d'or pour une application en IRM. Colloque Nanohybrides 2, Jun 2005, Autrans, France. ⟨ujm-00374952⟩
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Book sections

2012

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Christophe Alric, Rana Bazzi, François Lux, Laurent Gautier, Matteo Martini, et al.. The Design of Hybrid Nanoparticles for Image-Guided Radiotherapy. Chapter 7. Functional Nanoparticles for Bioanalysis, Nanomedicine, and Bioelectronic Devices, Hepel M. et al., ACS Symposium Series;American Chemical Society: Washington, DC, chapter 7, eds., pp.95-143, 2012, ⟨10.1021/bk-2012-1113.ch007⟩. ⟨hal-00820686⟩
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Patents

2005

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Francis Vocanson, Pj Debouttiere, R. Lamartine, Olivier Tillement, Stéphane Roux, et al.. Luminescent hybrid probes based on gold nanoparticles and method for preparation.. France, Patent n° : WO 2005054858. 2005, pp.36. ⟨ujm-00376167⟩
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Poster communications

2010

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Jean-Luc Coll, Sandrine Dufort, Lucie Sancey, Véronique Josserand, M Kéramidas, et al.. Optical imaging and Cancer: From mice to man. World Molecular Imaging Congress, 2010, Kyoto, Japan. 2010. ⟨hal-03179473⟩
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