Didier HOCQUET

Site Hauts du Chazal
UFR Sciences de la Santé
19, rue Ambroise Paré
25000 Besançon cedex 3, France

Didier Hocquet

Professor
PATHOGENES

dhocquet@-Code to remove to avoid SPAM-univ-fcomte.fr
+33 (0)3 70 63 21 34, room R212

Antibiotic resistance, healthcare-associated infections, Gram-negative bacilli, epidemiology, One Health

As a pharmacist-biologist with a PhD and HDR, I am interested in the emergence and spread of antibiotic-resistant bacteria. Our group has assessed the impact of antibiotic consumption and the role of the SOS response on the emergence of resistant pathogenic bacteria. We have also explored the spread of multi-resistant bacteria in hospitals, in the environment and in animals. Our work is based on the analysis of large collections of bacterial strains using experimental approaches (molecular biology, phenotypic analyses) and genomic approaches (based on the sequencing of complete genomes and their analysis using bioinformatics).

Current projects :

ALIMBRA project (Bourgogne Franche-Comté region, 2020-2023, principal investigator): The role of diet in the colonisation of the digestive microbiota by antibiotic-resistant pathogenic bacteria.
MEHTA project (ANR PPR Antibiotic resistance, 2023-2025, associate investigator): Managing Environmental Hotspots and Transmission of AMR

 

Journal articles

2022

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Anno de Jong, Farid El Garch, Didier Hocquet, Ellen Prenger-Berninghoff, Jeroen Dewulf, et al.. European-wide antimicrobial resistance monitoring in commensal Escherichia coli isolated from healthy food animals between 2004 and 2018. Journal of Antimicrobial Chemotherapy, 2022, 77 (12), pp.3301 - 3311. ⟨10.1093/jac/dkac318⟩. ⟨anses-03921929⟩
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Guillaume Miltgen, Daniel Martak, Benoit Valot, Laure Kamus, Thomas Garrigos, et al.. One Health compartmental analysis of ESBL-producing Escherichia coli on Reunion Island reveals partitioning between humans and livestock. Journal of Antimicrobial Chemotherapy, 2022, 77 (5), pp.1254-1262. ⟨10.1093/jac/dkac054⟩. ⟨hal-03830253⟩
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https://hal.inrae.fr/hal-03830253/file/dkac054.pdf BibTex
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Nadia Morin-Crini, Eric Lichtfouse, Guorui Liu, Vysetti Balaram, Ana Rita Lado Ribeiro, et al.. Worldwide cases of water pollution by emerging contaminants: a review. Environmental Chemistry Letters, 2022, 20, pp.2311-2338. ⟨10.1007/s10311-022-01447-4⟩. ⟨hal-03662990⟩
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2021

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Pierre Edwige L Fils, Pascal Cholley, Houssein Gbaguidi-Haore, Didier Hocquet, Marlène Sauget, et al.. ESBL-producing Klebsiella pneumoniae in a University hospital: Molecular features, diffusion of epidemic clones and evaluation of cross-transmission. PLoS ONE, 2021, 16 (3), pp.e0247875. ⟨10.1371/journal.pone.0247875⟩. ⟨hal-03356812⟩
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Daniel Martak, Julia Guther, Tess Verschuuren, Benoit Valot, Nadine Conzelmann, et al.. Populations of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae are different in human-polluted environment and food items: a multicentre European study. Clinical Microbiology and Infection, 2021, ⟨10.1016/j.cmi.2021.07.022⟩. ⟨hal-03360863⟩
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Allison Muller, Houssein Gbaguidi-Haore, Pascal Cholley, Didier Hocquet, Marlène Sauget, et al.. Hospital-diagnosed infections with Escherichia coli clonal group ST131 are mostly acquired in the community. Scientific Reports, 2021, 11 (1), pp.5702. ⟨10.1038/s41598-021-85116-6⟩. ⟨hal-03356640⟩
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Marie Petitjean, Paulo Juarez, Alexandre Meunier, Etienne Daguindau, Hélène Puja, et al.. The rise and the fall of a Pseudomonas aeruginosa endemic lineage in a hospital. Microbial Genomics, 2021, 7 (9), ⟨10.1099/mgen.0.000629⟩. ⟨hal-03356587⟩
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Maria Riccio, Tess Verschuuren, Nadine Conzelmann, Daniel Martak, Alexandre Meunier, et al.. Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients. Clinical Microbiology and Infection, 2021, 27 (9), pp.1322-1329. ⟨10.1016/j.cmi.2020.12.024⟩. ⟨hal-03360855⟩
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Yaëlle Roina, Frédéric Auber, Didier Hocquet, Guillaume Herlem. ePTFE ‐based biomedical devices: An overview of surgical efficiency. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2021, ⟨10.1002/jbm.b.34928⟩. ⟨hal-03356822⟩
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2020

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Kevin Bouiller, Didier Hocquet, Marlene Sauget, Xavier Bertrand, Catherine Chirouze. Epidemiology and risk factors of Staphylococcus aureus CC398 bone and joint infections. BMC Infectious Diseases, 2020, 20 (1), pp.384. ⟨10.1186/s12879-020-05098-0⟩. ⟨hal-03040589⟩
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Kevin Bouiller, Xavier Bertrand, Didier Hocquet, Catherine Chirouze. Human Infection of Methicillin-Susceptible Staphylococcus aureus CC398: A Review. Microorganisms, 2020, 8 (11), pp.1737. ⟨10.3390/microorganisms8111737⟩. ⟨hal-03037830⟩
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Emilia Chiapponi, Charles Henriot, Xavier Bertrand, Didier Hocquet, Gudrun Bornette. Using GFP-Tagged Escherichia coli to Investigate the Persistence of Fecal Bacteria in Vegetated Wetlands: An Experimental Approach. Antibiotics, 2020, 9 (6), pp.335. ⟨10.3390/antibiotics9060335⟩. ⟨hal-03040863⟩
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Farid El Garch, Myriam Youala, Shabbir Simjee, Hilde Moyaert, Rebecca Klee, et al.. Antimicrobial susceptibility of nine udder pathogens recovered from bovine clinical mastitis milk in Europe 2015–2016: VetPath results. Veterinary Microbiology, 2020, 245, pp.108644. ⟨10.1016/j.vetmic.2020.108644⟩. ⟨hal-03054008⟩
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Claire Amaris Hobson, Stéphane Bonacorsi, Didier Hocquet, André Baruchel, Mony Fahd, et al.. Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam. Scientific Reports, 2020, 10 (1), pp.589. ⟨10.1038/s41598-020-57505-w⟩. ⟨inserm-02490753⟩
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https://inserm.hal.science/inserm-02490753/file/s41598-020-57505-w.pdf BibTex
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José-María López-Lozano, Timothy Lawes, César Nebot, Arielle Beyaert, Xavier Bertrand, et al.. Author Correction: A nonlinear time-series analysis approach to identify thresholds in associations between population antibiotic use and rates of resistance. Nature Microbiology, 2020, 5 (11), pp.1449-1449. ⟨10.1038/s41564-020-00796-6⟩. ⟨hal-03053749⟩
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Alexandre Luscher, Juliette Simonin, Léna Falconnet, Benoit B. Valot, Didier Hocquet, et al.. Combined Bacteriophage and Antibiotic Treatment Prevents Pseudomonas aeruginosa Infection of Wild Type and cftr- Epithelial Cells. Frontiers in Microbiology, 2020, 11, pp.1947. ⟨10.3389/fmicb.2020.01947⟩. ⟨hal-03054559⟩
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Daniel Martak, Charles Henriot, Marion Broussier, Charlotte Couchoud, Benoit Valot, et al.. High Prevalence of Human-Associated Escherichia coli in Wetlands Located in Eastern France. Frontiers in Microbiology, 2020, 11, pp.552566. ⟨10.3389/fmicb.2020.552566⟩. ⟨hal-03040847⟩
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https://hal.science/hal-03040847/file/daniel%202020.pdf BibTex
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Chao Yuan, Yafeng Ma, Yinjuan Wang, Xiuli Wang, Chunyan Qian, et al.. Rosacea is associated with conjoined interactions between physical barrier of the skin and microorganisms: A pilot study. Journal of Clinical Laboratory Analysis, 2020, 34 (9), pp.e23363. ⟨10.1002/jcla.23363⟩. ⟨hal-03053773⟩
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2019

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Audrey Emery, Audrey Jeanvoine, Pascale Bailly, Houssein Gbaguidi-Haore, Didier Hocquet, et al.. Management of carbapenemase-producing Enterobacteriaceae in a low incidence area: A six-year experience in a university hospital. Infection Control and Hospital Epidemiology, 2019, 40 (8), pp.936-938. ⟨10.1017/ice.2019.149⟩. ⟨hal-02315688⟩
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Charles Henriot, Daniel Martak, Quentin Cuenot, Christophe Loup, Hélène Masclaux, et al.. Occurrence and ecological determinants of the contamination of floodplain wetlands with Klebsiella pneumoniae and pathogenic or antibiotic-resistant Escherichia coli. FEMS Microbiology Ecology, 2019, 95 (8), ⟨10.1093/femsec/fiz097⟩. ⟨hal-02315686⟩
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Audrey Jeanvoine, Alexandre Meunier, Hélène Puja, Xavier Bertrand, Benoît Valot, et al.. Contamination of a hospital plumbing system by persister cells of a copper-tolerant high-risk clone of Pseudomonas aeruginosa. Water Research, 2019, 157, pp.579-586. ⟨10.1016/j.watres.2019.04.011⟩. ⟨hal-02315692⟩
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José-María López-Lozano, Timothy Lawes, César Nebot, Arielle Beyaert, Xavier Bertrand, et al.. A nonlinear time-series analysis approach to identify thresholds in associations between population antibiotic use and rates of resistance. Nature Microbiology, 2019, 4 (7), pp.1160-1172. ⟨10.1038/s41564-019-0410-0⟩. ⟨hal-02315695⟩
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Daniel Martak, Benoît Valot, Marlène Sauget, Pascal Cholley, Michelle Thouverez, et al.. Fourier-Transform InfraRed Spectroscopy Can Quickly Type Gram-Negative Bacilli Responsible for Hospital Outbreaks. Frontiers in Microbiology, 2019, 10, pp.1440. ⟨10.3389/fmicb.2019.01440⟩. ⟨hal-02315678⟩
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Anaïs Potron, Didier Hocquet, Pauline Triponney, Patrick Plesiat, Xavier Bertrand, et al.. Carbapenem-Susceptible OXA-23-Producing Proteus mirabilis in the French Community. Antimicrobial Agents and Chemotherapy, 2019, 63 (6), ⟨10.1128/AAC.00191-19⟩. ⟨hal-02315697⟩
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Marlène Sauget, Kévin Bouiller, Marion Richard, Juliette Chagrot, Pascal Cholley, et al.. Increasing incidence of bloodstream infections due to Staphylococcus aureus clonal complex 398 in a French hospital between 2010 and 2017. European Journal of Clinical Microbiology and Infectious Diseases, 2019, ⟨10.1007/s10096-019-03653-5⟩. ⟨hal-02315676⟩
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Celine Slekovec, jerome robert, Nathalie van Der Mee-Marquet, Philippe Berthelot, Anne-Marie Rogues, et al.. Molecular epidemiology of Pseudomonas aeruginosa isolated from infected ICU patients: a French multicenter 2012–2013 study. European Journal of Clinical Microbiology and Infectious Diseases, 2019, 38 (5), pp.921-926. ⟨10.1007/s10096-019-03519-w⟩. ⟨hal-02083439⟩
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2018

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Kévin Bouiller, Caroline Laborde, Serge Ludwig Aho, Didier Hocquet, André Pechinot, et al.. No effect of vancomycin MIC ≥ 1.5 mg/L on treatment outcome in methicillin-susceptible Staphylococcus aureus bacteraemia. International Journal of Antimicrobial Agents, 2018, 51 (5), pp.721 - 726. ⟨10.1016/j.ijantimicag.2017.12.028⟩. ⟨hal-01812627⟩
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Hélène Bouxom, Damien Fournier, Kévin Bouiller, Didier Hocquet, Xavier Bertrand. Which non-carbapenem antibiotics are active against extended-spectrum β-lactamase-producing Enterobacteriaceae?. International Journal of Antimicrobial Agents, 2018, 52 (1), pp.100-103. ⟨10.1016/j.ijantimicag.2018.03.014⟩. ⟨hal-01812635⟩
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Farid El Garch, Anno de Jong, Xavier Bertrand, Didier Hocquet, Marlène Sauget. mcr-1- like detection in commensal Escherichia coli and Salmonella spp. from food-producing animals at slaughter in Europe. Veterinary Microbiology, 2018, 213, pp.42 - 46. ⟨10.1016/j.vetmic.2017.11.014⟩. ⟨hal-01712188⟩
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Houssein Gbaguidi-Haore, Amélie Varin, Pascal Cholley, Michelle Thouverez, Didier Hocquet, et al.. A Bundle of Measures to Control an Outbreak of Pseudomonas aeruginosa Associated With P-Trap Contamination. Infection Control and Hospital Epidemiology, 2018, 39 (02), pp.164 - 169. ⟨10.1017/ice.2017.304⟩. ⟨hal-01812624⟩
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Guillaume Miltgen, Rémy Bonnin, Catherine Avril, Thierry Benoit-Cattin, Daniel Martak, et al.. Outbreak of IMI-1 carbapenemase-producing colistin-resistant Enterobacter cloacae on the French island of Mayotte (Indian Ocean). International Journal of Antimicrobial Agents, 2018, 52 (3), pp.416-420. ⟨10.1016/j.ijantimicag.2018.05.015⟩. ⟨hal-01982352⟩
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Marlène Sauget, Xavier Bertrand, Didier Hocquet. Rapid antibiotic susceptibility testing on blood cultures using MALDI-TOF MS. PLoS ONE, 2018, 13 (10), pp.e0205603. ⟨10.1371/journal.pone.0205603⟩. ⟨hal-02315723⟩
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Panisa Treepong, Christophe Guyeux, Alexandre Meunier, Charlotte Couchoud, Didier Hocquet, et al.. panISa: Ab initio detection of insertion sequences in bacterial genomes from short read sequence data. Bioinformatics, 2018, 34 (22), pp.3795-3800. ⟨10.1093/bioinformatics/bty479⟩. ⟨hal-02438015⟩
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2017

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Hélène Bouxom, Damien Fournier, Kévin Bouiller, Didier Hocquet, Xavier Bertrand, et al.. Association between Pseudomonas aeruginosa positive water samples and healthcare-associated cases: nine-year study at one university hospital. Journal of Hospital Infection, 2017, 96 (3), pp.238 - 243. ⟨10.1016/j.jhin.2016.12.007⟩. ⟨hal-01863884⟩
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Clara Mariette, Emmanuel Tavernier, Didier Hocquet, Anne Huynh, Françoise Isnard, et al.. Epidemiology of invasive fungal infections during induction therapy in adults with acute lymphoblastic leukemia: a GRAALL-2005 study.. Leukemia & lymphoma, 2017, 58 (3), pp.586-593. ⟨10.1080/10428194.2016.1204652⟩. ⟨hal-01508753⟩
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Marie Nicolas-Chanoine, Marie Petitjean, Azucena Mora, Noémie Mayer, Jean-Philippe Lavigne, et al.. The ST131 Escherichia coli H22 subclone from human intestinal microbiota: Comparison of genomic and phenotypic traits with those of the globally successful H30 subclone.. BMC Microbiology, 2017, 17, pp.71. ⟨10.1186/s12866-017-0984-8⟩. ⟨hal-01508750⟩
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Marie Petitjean, Daniel Martak, Alicia Silvant, Xavier Bertrand, Benoit Valot, et al.. Genomic characterization of a local epidemic Pseudomonas aeruginosa reveals specific features of the widespread clone ST395. Microbial Genomics, 2017, 3 (10), ⟨10.1099/mgen.0.000129⟩. ⟨hal-01664243⟩
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Marlène Sauget, Benoît Valot, Xavier Bertrand, Didier Hocquet. Can MALDI-TOF Mass Spectrometry Reasonably Type Bacteria?. Trends in Microbiology, 2017. ⟨hal-01505999⟩
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Amélie Varin, Benoît Valot, Pascal Cholley, Camille Morel, Michelle Thouverez, et al.. High prevalence and moderate diversity of Pseudomonas aeruginosa in the U-bends of high-risk units in hospital. International Journal of Hygiene and Environmental Health, 2017, 220 (5), pp.880 - 885. ⟨10.1016/j.ijheh.2017.04.003⟩. ⟨hal-01664766⟩
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2016

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Marisa Haenni, Estelle Saras, Cécile Ponsin, Safia Dahmen, Marie Petitjean, et al.. High prevalence of international ESBL CTX-M-15-producing Enterobacter cloacae ST114 clone in animals.. Journal of Antimicrobial Chemotherapy, 2016. ⟨hal-01306082⟩
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Didier Hocquet, Marie Petitjean, Laurence Rohmer, Benoît Valot, Hemantha D Kulasekara, et al.. Pyomelanin-producing Pseudomonas aeruginosa selected during chronic infections have a large chromosomal deletion which confers resistance to pyocins.. Environmental Microbiology, 2016, 18 (10), pp.3482-3493. ⟨10.1111/1462-2920.13336⟩. ⟨hal-01508741⟩
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Marlène Sauget, Pascal Cholley, Andréa Vannier, Michelle Thouverez, Marie-Hélène Nicolas-Chanoine, et al.. Trends of extended-spectrum β-lactamase-producing Escherichia coli sequence type 131 and its H30 subclone in a French hospital over a 15-year period.. International Journal of Antimicrobial Agents, 2016, 48 (6), pp.744-747. ⟨10.1016/j.ijantimicag.2016.09.023⟩. ⟨hal-01506043⟩
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Marlène Sauget, Nathalie van Der Mee-Marquet, Xavier Bertrand, Didier Hocquet. Matrix-assisted laser desorption ionization-time of flight Mass spectrometry can detect Staphylococcus aureus clonal complex 398.. Journal of Microbiological Methods, 2016, 127, pp.20-3. ⟨10.1016/j.mimet.2016.05.010⟩. ⟨hal-01507182⟩
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Marie Titecat, Xiaofei Liang, Chul-Jin Lee, Audrey Charlet, Didier Hocquet, et al.. High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.. Journal of Antimicrobial Chemotherapy, 2016, 71 (10), pp.2874-82. ⟨10.1093/jac/dkw210⟩. ⟨hal-01508758⟩
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2015

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Nadège Cabrolier, Marlène Sauget, Xavier Bertrand, Didier Hocquet. Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry identifies Pseudomonas aeruginosa high-risk clones.. Journal of Clinical Microbiology, 2015, pp.210-15. ⟨hal-01114612⟩
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Pascal Cholley, Milos Stojanov, Didier Hocquet, Michelle Thouverez, Xavier Bertrand, et al.. Comparison of double-locus sequence typing (DLST) and multilocus sequence typing (MLST) for the investigation of Pseudomonas aeruginosa populations.. Diagnostic Microbiology and Infectious Disease, 2015, 82 (4), pp.274-7. ⟨hal-01306065⟩
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Marisa Haenni, Didier Hocquet, Cécile Ponsin, Pascal Cholley, Christophe Guyeux, et al.. Population structure and antimicrobial susceptibility of Pseudomonas aeruginosa from animal infections in France. BMC Veterinary Research, 2015, 11 (9), 5 p. ⟨10.1186/s12917-015-0324-x⟩. ⟨hal-02131125⟩
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Benoît Valot, Christophe Guyeux, Julien y Rolland, Kamel Mazouzi, Xavier Bertrand, et al.. What it takes to be a Pseudomonas aeruginosa? The core genome of the opportunistic pathogen updated. PLoS ONE, 2015, 10 (5), pp.e0126468. ⟨10.1371/journal.pone.0126468⟩. ⟨hal-02131118⟩
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2014

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Caroline Bréchet, Julie Plantin, Marlène Sauget, Michelle Thouverez, Daniel Talon, et al.. Wastewater Treatment Plants Release Large Amounts of Extended-Spectrum β-Lactamase-Producing Escherichia coli Into the Environment.. Clinical Infectious Diseases, 2014, epub ahead of print. ⟨10.1093/cid/ciu190⟩. ⟨hal-00994515⟩
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Pascal Cholley, Roughyatou Ka, Christophe Guyeux, Michelle Thouverez, Nathalie Guessennd, et al.. Population Structure of Clinical Pseudomonas aeruginosa from West and Central African Countries.. PLoS ONE, 2014, 9 (9), pp.e107008. ⟨10.1371/journal.pone.0107008⟩. ⟨hal-01061603⟩
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Thomas Guillard, Pascal Cholley, Anne Limelette, Didier Hocquet, Lucie Matton, et al.. Fluoroquinolone Resistance Mechanisms and population structure of Enterobacter cloacae non-susceptible to Ertapenem in North-Eastern France.. Frontiers in Microbiology, 2014, 6, pp.1186. ⟨10.3389/fmicb.2015.01186⟩. ⟨hal-01306039⟩
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Didier Hocquet, Marlène Sauget, Sandrine Roussel, Caroline Malugani, Fabienne Pouthier, et al.. Validation of an automated blood culture system for sterility testing of cell therapy products.. Cytotherapy, 2014, 16 (5), pp.692-698. ⟨10.1016/j.jcyt.2013.09.005⟩. ⟨hal-00912385⟩
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Jeremy Lafolie, Marie-Hélène Nicolas-Chanoine, Frédéric Grenouillet, Didier Hocquet, Xavier Bertrand. Prevalence of Escherichia coli sequence type 131 and its H30 subclone among E. coli isolates in a French hospital.. International Journal of Antimicrobial Agents, 2014, 44 (5), pp.466-8. ⟨hal-01114505⟩
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Laurence Rohmer, Michael A Jacobs, Mitchell J Brittnacher, Christine Fong, Hillary S Hayden, et al.. Genomic analysis of the emergence of 20th century epidemic dysentery.. BMC Genomics, 2014, 15, pp.355. ⟨10.1186/1471-2164-15-355⟩. ⟨hal-01061621⟩
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Marlène Sauget, Nadège Cabrolier, Marion Manzoni, Xavier Bertrand, Didier Hocquet. Rapid, sensitive and specific detection of OXA-48-like-producing Enterobacteriaceae by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.. Journal of Microbiological Methods, 2014, 105C, pp.88-91. ⟨10.1016/j.mimet.2014.07.004⟩. ⟨hal-01061607⟩
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Marlène Sauget, Marie-Hélène Nicolas-Chanoine, Nadège Cabrolier, Xavier Bertrand, Didier Hocquet. Matrix-assisted laser desorption ionization-time of flight mass spectrometry assigns Escherichia coli to the phylogroups A, B1, B2 and D.. International Journal of Medical Microbiology, 2014, epub ahead of print. ⟨10.1016/j.ijmm.2014.06.004⟩. ⟨hal-01061605⟩
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Benoit Valot, Laurence Rohmer, Michael A Jacobs, Samuel I Miller, Xavier Bertrand, et al.. Comparative Genomic Analysis of Two Multidrug-Resistant Clinical Isolates of ST395 Epidemic Strain of Pseudomonas aeruginosa Obtained 12 Years Apart.. Genome Announc, 2014, 2 (3), epub ahead of print. ⟨10.1128/genomeA.00515-14⟩. ⟨hal-01061619⟩
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2013

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Houssein Gbaguidi-Haore, Daniel Talon, Didier Hocquet, Xavier Bertrand. Hospital environmental contamination with Enterobacteriaceae producing extended-spectrum β-lactamase.. American Journal of Infection Control, 2013, epub ahead of print. ⟨10.1016/j.ajic.2012.07.021⟩. ⟨hal-00802678⟩
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Houssein Gbaguidi-Haore, Catherine Dumartin, François L'Hériteau, Muriel Péfau, Didier Hocquet, et al.. Antibiotics involved in the occurrence of antibiotic-resistant bacteria: a nationwide multilevel study suggests differences within antibiotic classes.. Journal of Antimicrobial Chemotherapy, 2013, 68 (2), pp.461-70. ⟨10.1093/jac/dks406⟩. ⟨hal-00802859⟩
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Didier Hocquet, Xavier Bertrand. Metronidazole increases the emergence of ciprofloxacin- and amikacin-resistant Pseudomonas aeruginosa by inducing the SOS response.. Journal of Antimicrobial Chemotherapy, 2013, epub ahead of print. ⟨10.1093/jac/dkt435⟩. ⟨hal-00926039⟩
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2012

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Didier Hocquet, Catherine Llanes, Michelle Thouverez, Hemantha D Kulasekara, Xavier Bertrand, et al.. Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting.. PLoS Pathogens, 2012, 8 (6), pp.e1002778. ⟨10.1371/journal.ppat.1002778⟩. ⟨hal-00802793⟩
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Céline Slekovec, Xavier Bertrand, Joël Leroy, Jean-Pierre Faller, Daniel Talon, et al.. Identifying Patients Harboring Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae on Hospital Admission Is Not That Simple.. Antimicrobial Agents and Chemotherapy, 2012, 56 (4), pp.2218-9. ⟨10.1128/AAC.06376-11⟩. ⟨hal-00682600⟩
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Céline Slekovec, Julie Plantin, Pascal Cholley, Michelle Thouverez, Daniel Talon, et al.. Tracking down antibiotic-resistant Pseudomonas aeruginosa isolates in a wastewater network.. PLoS ONE, 2012, 7 (12), pp.e49300. ⟨10.1371/journal.pone.0049300⟩. ⟨hal-00802679⟩
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2011

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Pascal Cholley, Michelle Thouverez, Didier Hocquet, Nathalie van Der Mee-Marquet, Daniel Talon, et al.. Most multidrug-resistant Pseudomonas aeruginosa isolates from hospitals in eastern France belong to a few clonal types.. Journal of Clinical Microbiology, 2011, 49 (7), pp.2578-83. ⟨10.1128/JCM.00102-11⟩. ⟨hal-00627171⟩
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Didier Hocquet, Barbara Dehecq, Xavier Bertrand, Patrick Plésiat. Strain-tailored double-disk synergy test detects extended-spectrum oxacillinases in Pseudomonas aeruginosa.. Journal of Clinical Microbiology, 2011, 49 (6), pp.2262-5. ⟨10.1128/JCM.02585-10⟩. ⟨hal-00627176⟩
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Didier Hocquet, Mélanie Colomb, Barbara Dehecq, Olivier Belmonte, Patrice Courvalin, et al.. Ceftazidime-hydrolysing β-lactamase OXA-145 with impaired hydrolysis of penicillins in Pseudomonas aeruginosa.. Journal of Antimicrobial Chemotherapy, 2011, 66 (8), pp.1745-50. ⟨10.1093/jac/dkr187⟩. ⟨hal-00668369⟩
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Laurence Rohmer, Didier Hocquet, Samuel I Miller. Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis.. Trends Microbiol, 2011, 19 (7), pp.341-8. ⟨10.1016/j.tim.2011.04.003⟩. ⟨hal-00668374⟩
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2010

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Pascal Cholley, Didier Hocquet, Corentine Alauzet, Aurelie Cravoisy, Daniel Talon, et al.. Hospital outbreak of P. aeruginosa producing extended-spectrum oxacillinase OXA-19.. Journal of Medical Microbiology, 2010, epub ahead of print. ⟨10.1099/jmm.0.019364-0⟩. ⟨hal-00474830⟩
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Didier Hocquet, Patrick Plésiat, Barbara Dehecq, Pierre Mariotte, Daniel Talon, et al.. Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France.. Antimicrobial Agents and Chemotherapy, 2010, 54 (8), pp.3512-5. ⟨10.1128/AAC.01646-09⟩. ⟨hal-00510525⟩
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2009

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Damien Fournier, Didier Hocquet, Barbara Dehecq, Pascal Cholley, Patrick Plésiat. Detection of a new extended-spectrum oxacillinase in Pseudomonas aeruginosa.. Journal of Antimicrobial Chemotherapy, 2009, epub ahead of print. ⟨10.1093/jac/dkp438⟩. ⟨hal-00448435⟩
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2008

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Didier Hocquet, Arno Muller, Karine Blanc, Patrick Plésiat, Daniel Talon, et al.. Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa.. Antimicrobial Agents and Chemotherapy, 2008, 52 (3), pp.1173-5. ⟨10.1128/AAC.01212-07⟩. ⟨hal-00341670⟩
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2007

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Farid El'Garch, Katy Jeannot, Didier Hocquet, Catherine Llanes-Barakat, Patrick Plésiat. Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.. Antimicrobial Agents and Chemotherapy, 2007, 51 (3), pp.1016-21. ⟨10.1128/AAC.00704-06⟩. ⟨hal-00464783⟩
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Didier Hocquet, Micheline Roussel-Delvallez, Jean-Didier Cavallo, Patrick Plésiat. MexAB-OprM- and MexXY-overproducing mutants are very prevalent among clinical strains of Pseudomonas aeruginosa with reduced susceptibility to ticarcillin.. Antimicrobial Agents and Chemotherapy, 2007, 51 (4), pp.1582-3. ⟨10.1128/AAC.01334-06⟩. ⟨hal-00464782⟩
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Didier Hocquet, Philippe Berthelot, Micheline Roussel-Delvallez, Roger Favre, Katy Jeannot, et al.. Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections.. Antimicrobial Agents and Chemotherapy, 2007, 51 (10), pp.3531-6. ⟨10.1128/AAC.00503-07⟩. ⟨hal-00464781⟩
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2006

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Didier Hocquet, Patrice Nordmann, Farid El Garch, Ludovic Cabanne, Patrick Plésiat. Involvement of the MexXY-OprM efflux system in emergence of cefepime resistance in clinical strains of Pseudomonas aeruginosa.. Antimicrobial Agents and Chemotherapy, 2006, 50 (4), pp.1347-51. ⟨10.1128/AAC.50.4.1347-1351.2006⟩. ⟨hal-00464785⟩
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2005

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Philippe Dupont, Didier Hocquet, Katy Jeannot, Pascal Chavanet, Patrick Plesiat. Bacteriostatic and bactericidal activities of eight fluoroquinolones against MexAB-OprM-overproducing clinical strains of Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, 2005, 55 (4), pp.518 - 522. ⟨10.1093/jac/dki030⟩. ⟨hal-01696246⟩
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Mara Sobel, Didier Hocquet, Lily Cao, Patrick Plesiat, Keith Poole. Mutations in PA3574 (nalD) Lead to Increased MexAB-OprM Expression and Multidrug Resistance in Laboratory and Clinical Isolates of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 2005, 49 (5), pp.1782 - 1786. ⟨10.1128/AAC.49.5.1782-1786.2005⟩. ⟨hal-01696230⟩
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2004

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Catherine Llanes, Didier Hocquet, Christelle Vogne, Dounia Benali-Baitich, Catherine Neuwirth, et al.. Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously.. Antimicrobial Agents and Chemotherapy, 2004, pp.1797-802. ⟨hal-01696285⟩
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Christelle Vogne, Julio Ramos Aires, Christiane Bailly, Didier Hocquet, Patrick Plesiat. Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis.. Antimicrobial Agents and Chemotherapy, 2004, pp.1676-80. ⟨hal-01696291⟩
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Conference papers

2015

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Huda Al-Nayyef, Christophe Guyeux, Marie Petitjean, Didier Hocquet, Jacques Bahi. Relation between Insertion Sequences and Genome Rearrangements in Pseudomonas aeruginosa. IWBBIO 2015, 3rd Int. Work-Conf. on Bioinformatics and Biomedical Engineering, 2015, Granada, Spain. pp.426-437. ⟨hal-01230840⟩
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Book sections

2021

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Charles Henriot, Daniel Martak, Christophe Dagot, Fabienne Petit, Edward Topp, et al.. The Fate of Antibiotic-Resistant Bacteria in the Environment. Emerging Contaminants Vol. 1, 65, Springer International Publishing, pp.207-260, 2021, Environmental Chemistry for a Sustainable World, ⟨10.1007/978-3-030-69079-3_4⟩. ⟨hal-03388911⟩
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Nadia Morin-Crini, Eric Lichtfouse, Guorui Liu, Vysetti Balaram, Ana Rita Lado Ribeiro, et al.. Emerging contaminants: analysis, aquatic compartments and water pollution. Lichtfouse E., Schwarzbauer J., Didier R. Emerging Contaminants Vol. 1 Occurrence and Impact, 65, Springer Nature, pp.1 - 111, 2021, Environmental Chemistry for a Sustainable World, 978-3-030-69078-6. ⟨10.1007/978-3-030-69079-3_1⟩. ⟨hal-03555567⟩
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https://hal.science/hal-03555567/file/Morin-CriniEmerging2021revised.pdf BibTex

2015

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Huda Al-Nayyef, Christophe Guyeux, Marie Petitjean, Didier Hocquet, Jacques Bahi. Relation between Insertion Sequences and Genome Rearrangements in Pseudomonas aeruginosa. Bioinformatics and Biomedical Engineering, 9043, Springer International Publishing, pp.426-437, 2015, Lecture Notes in Computer Science, ⟨10.1007/978-3-319-16483-0_42⟩. ⟨hal-03496936⟩
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https://arxiv.org/pdf/1706.08119 BibTex

Reports

2020

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Didier Hocquet, Pierre Maris, Sandrine Baron, Delphine Bibbal, Olivier Chesneau, et al.. Antibiorésistance et environnement - État et causes possibles de la contamination des milieux en France par les antibiotiques, les bactéries résistantes aux antibiotiques et les supports génétiques de la résistance aux antibiotiques. Saisine n°2016-SA-025, Anses. 2020, 263 p. ⟨anses-04301762⟩
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